Before emigrating to America on the "Mayflower", Samuel went to Holland in 1608. He was a doctor. When his nephew, also named Samuel was orphaned in 1621, he took him in and raised him. When he died in 1633, his 21 year old nephew was the executor of his estate.
Dr. Samuel Fuller, was one of the band of Pligrims that fled England to Leydon, Holland in 1609. Deacon of the Church at both Leydon and Plymouth; one of the 41 signers of the Mayflower Compact; Physician and Surgeon to Plymouth Colony and later to the Mass. Bay Colony. 1632 was a member of Governor's Council called assistants. His servant, William Butten, was the only passenger to die enroute on the Mayflower. Samuel's wife Bridget and child came in 1623 on Anne. Samuel died during the 1633 epidemic of smallpox.