During her lifetime, Elizabeth Willoughby wedded three husbands. The first was Simon Overzee, a Dutch merchant who traded widely in the lower James River bain, the counties along the Chesapeake Bay, and Maryland.
Overzee died in 1660, and within the year Elizabeth took her second husband, George Colclough. The younger brother of a wealthy, well-placed London grocer, and himself a merchant, Colclough had settled in Northumberland County around 1651. By 1656 he was a magistrate and a burgess for the county. The marriage lasted until Colclough's death in 1662.
Thereupon, the widow Colclough married Isaac Allerton, the son of a Plymouth, Massachusetts merchant who also resided in Northumberand. She was Isaac Allerton's second wife. Either just before of soon after they were wed, Allerton was commissioned a justice of the peace. Subsequently he became a member of the House of Burgesses and eventually won a seat on the governor's council.
"The Old Dominion in the Seventeenth Century"
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She was mentioned in an April 1672 letter from Governor CharlesCalvert to Cecilius, 2nd Lord Baltimore regarding Maryland landrights of her deceased first husband (Simon Overzee).