He married, firstly, Joan FitzAlan, daughter of Sir Thomas FitzAlan, 17th Earl of Arundel and Margaret Woodville, before 1494. He married, secondly, Margaret Brent, daughter of William Brent and Anne Rosmoderes, before 21 December 1495. He married, thirdly, Lady Mary Stafford, daughter of Sir Edward Stafford, 3rd Duke of Buckingham and Lady Eleanor Percy, circa June 1519. He married, fourthly, Mary Brooke after 1520.
Sir George was invested as a Knight, Order of the Bath (K.B.) on 4 July 1483. He succeeded to the title of 3rd Lord Abergavenny [E., 1450] on 20 September 1492. He fought in the Battle of Blackheath on 17 June 1497, against the Cornish Rebels. He held the office of Constable of Dover Castle. He held the office of Chief Larderer at the coronation of King Henry VIII in 1509. On 18 December 1512 King Henry VIII granted him the castle and lands of Abergavenny. He held the office of Warden of the Cinque Ports in 1513. He was invested as a Knight, Order of the Garter (K.G.) on 23 April 1513. He held the office of Keeper of Ashdown Forest in 1515. He was invested as a Privy Counsellor (P.C.) in 1516. From 1521 to 1522 he was imprisoned on suspicion of conspiring with his father-in-law, the Duke of Buckingham. He held the office of Chief Larderer at the coronation of Anne Boleyn in 1533.
Child of Sir George Neville, 3rd Lord Abergavenny and Joan FitzAlan
* Lady Elizabeth Neville b. b 1495
Children of Sir George Neville, 3rd Lord Abergavenny and Lady Mary Stafford
* Sir Henry Neville, 4th Lord Abergavenny b. bt 1527 - 1535, d. 10 Feb 1586/87
* Lady Dorothy Neville b. b 1535, d. 22 Sep 1559
* Lady Mary Neville b. b 1535, d. c 1576
* John Neville b. b 1535
* Thomas Neville b. b 1535
* Lady Catherine Neville b. b 1535
* Lady Margaret Neville b. b 1535
* Lady Joan Neville b. b 1535
* Lady Ursula Neville b. b 1535, d. 1575
Sir George Neville, 5th Baron Bergavenny (3rd Lord Bergavenny) 
- b.~ 1364 d.21 Oct 1425
