According to "Howe's Historical Collection of Ohio" by Henry Howe, he was one of the first settlers in Champaign County. The History of Champaign County says he came to Ohio in 1799. He settled on the Mad River, in what later became Champaign County. When Urbana was later laid out, he moved to town and started a pottery. He also engaged in the mercantile business, was quite active in local politics, and served as one of the early sheriffs of the county, from 1821 to 1825 and 1833 to 1847. He was listed as an Elector for Champaign County, 8 Oct 1811; no. 22 in a list of 87 voters. He was also elected Treasurer of the County from 1840 to 1847. He and and his first wife, Jennie, had nine children, but only four have been found.
In Chancery Records for Champaign Co. Vol. 1, there are 11 references to Frederick Ambrose. No other Ambrose is named. The early references are to service on the grand or petit jury. In 1833 Frederick Ambrose was appointed guardian ad litem for the Hanback children [pg. 78]; and for the Taylor children [pg. 80]; also for Lung children [pg 92]. Frederick Ambrose admin. of Alexander Allen vs.. Sally Allen et al. Has to do with selling of a lot owned by Alexander Allen. In 1838 Frederick Ambrose admin. of Wm. Winsor deceased v. Hannah Weldon et al. Again, having to do with lot in Urbana.